On the 2005 Ford Expedition, the P0453 is a fairly straight forward code pointing to a fault with the Fuel Tank Pressure Sensor. You can find the sensor located at the top of the fuel tank. To gain proper access, the tank will need to be removed. Very commonly here, the plastic tube gets a crack in it. Make sure to carefully inspect the electrical connector and wire harness for any loose, broken or damaged wires. If the visual inspection checks ok, replacing the Fuel Tank Pressure Sensor Assembly (comes with new plastic lines) should solve the problem.
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