On the 2001 Chevy S10 Blazer, the P0453 is a fairly straight forward code that points to a problem with the Fuel Tank Pressure Sensor. The FTP sensor is located at the top of the fuel tank, mounted to the top of the fuel pump assembly. To gain access, the fuel tank will need to be removed from the vehicle. Once removed, carefully inspect the electrical connector and wire harness for any loose, broken or damaged wires (inspect carefully, a rubbed-through wire in the harness is very common on these vehicles). If no problems are found in the wiring, replacing the FTP sensor will solve the problem.
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